Most episodes of uncomplicated cellulitis are caused by Staphylococcus aureus or beta-hemolytic streptococci. Because of their good activity against these organisms and their relatively narrow spectrum of activity, first-generation cephalosporins (i.e. cefazolin iv or cephalexin po) are often considered first-line agents. Cefazolin alone is best given iv every eight hours. However, if probenecid is co-administered orally, then the dosing interval of cefazolin can be prolonged to every 24 hours. This may be much more practical, especially in the management of outpatients. While the use of cefazolin/probenecid appears to have comparable efficacy in mild to moderate cases, I’d recommend that standard iv dose cefazolin be used in more severe cases.

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