Oral vitamin D supplementation (cholecalciferol vitamin D₃) is effective for vitamin D supplementation in individuals with low vitamin D, as long as they have normal absorption. Severe nutritional deficiency (25-OH-D < 50 nmol/L) requires initial treatment with 50,000 international units of D3 orally once per week for six to eight weeks, and then 800 to 1,000 units of vitamin D₃ daily thereafter. If the vitamin D level is not improving, workup for malabsorption — such as screening for celiac disease — should be considered.

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