The long-term complications of H1N1 infection will largely be dictated by the severity of the acute disease and underlying co-morbidities. The majority of patients who have H1N1 infection will recover without any long-term effect. However, those that have severe disease may have multisystem complications that can include acute respiratory distress syndrome (ARDS), myopathy, acute renal failure, shock, and encephalopathy. Patients such as these may have prolonged need for supplemental oxygen, reduced exercise capacity, weakness, difficulty ambulating, and have generally reduced quality of life that may persist for months or years following the critical illness.