Chemo undermines vaccination
Does chemotherapy have a negative effect on vaccine-induced immunity? If so, should we be checking pre- and post-treatment titres? DARREN CARGILL, MD, Windsor, ON
Chemotherapy by its nature affects rapidly growing cells, so it can modulate the immune response to vaccines. I generally try to time the chemotherapy to avoid this in patients who are due for vaccination. If titres are of a sort that can be measured, then that may be worthwhile to ensure immunity has been conferred.