The simple answer is that we don’t have a lot of good solutions to this awful problem. Cancer patients often find that food doesn’t appeal to them. It tastes different and the texture is not right. The first thing I do is ask the patient to switch to eating small frequent meals and avoiding anything that has too much of a smell, too hot, too cold, too spicy or too large a portion. Even cooking the food can turn them off it. I would try that first. Other options include a small amount of alcohol prior to meals, steroids, and megesterol acetate at minimal 160 mg a day or higher. Occasionally, a patient finds marijuana helpful. All these have potential toxicities that may outweigh the benefits.