question and answer
PMR: WHEN, IF EVER, TO STOP PREDNISONE?
August 2000
"A patient with polymyalgia rheumatica (PMR) told me that her specialist said her disease is 'burnt out,' because her sedimentation rate is normal, yet she's still on prednisone," explains CATHY ANDREW, MD, of Toronto, ON. She asks: "Will she be able to come off the drug eventually after 10 years?"
The problem with PMR is that, while it's generally very responsive to treatment, sometimes it's impossible to get the patient completely off prednisone -- even after prolonged therapy. Very low doses (e.g. 1-3 mg per day) may still be required to control symptoms. There's no harm, however, in trying to wean off the drug slowly, but the potential for relapse does exist. Alternatives for symptom control include nonsteroidal antiinflammatory drugs (NSAIDs) but, in the elderly, a low dose of prednisone is probably safer and usually more effective. LR
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